Diadenosine polyphosphates in the tears of aniridia patients
نویسندگان
چکیده
منابع مشابه
Diadenosine polyphosphates in the tears of aniridia patients.
PURPOSE To quantify diadenosine polyphosphate levels in tears of congenital aniridia patients to estimate the ocular surface changes associated with congenital aniridia compared to normal individuals. METHODS Fifteen patients diagnosed with congenital aniridia and a control group of forty volunteers were studied. Tears were collected to quantify the levels of diadenosine polyphosphates Ap4 A ...
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PURPOSE To investigate the influence of diadenosine polyphosphates on the rate of corneal epithelial cell migration. METHODS Primary corneal epithelial cell cultures were obtained from New Zealand White rabbits. Immunocytochemical experiments were performed by fixing the cells with 4% paraformaldehyde (PFA) and incubated with cytokeratin 3 primary antibody, which was subsequently incubated wi...
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Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous, naturally occurring molecules. They form a recently identified class of compounds derived from ATP and consist of two adenosine molecules bridged by up to six phosphate groups. These compounds are stored in high concentrations in platelet dense granules and are released when platelets become ac...
متن کاملVasoactivity of diadenosine polyphosphates in human small renal resistance arteries.
BACKGROUND We examined for the first time the vascular effects of purinergic agents that contribute to the regulation of peripheral vascular resistance in human small renal resistance arteries (hRRAs). METHODS AND RESULTS Diadenosine polyphosphates (ApnAs, n = 3-6) and ATP, mounted in a microvessel myograph, caused vasoconstriction in hRRAs (rank order of potency: Ap5A > Ap6A = Ap4A > Ap3A = ...
متن کاملIncreased levels of diadenosine polyphosphates in dry eye.
PURPOSE To analyze the levels of the diadenosine polyphosphates Ap4A and Ap5A in tears, in a set of control subjects and in groups of symptomatic and nonsymptomatic persons with dry eye. METHODS Ninety-seven subjects participated in the study. The subjects were divided into five experimental groups: control subjects; symptomatic patients with normal tear secretion; symptomatic patients with l...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2014
ISSN: 1755-375X
DOI: 10.1111/aos.12626